Effect of Soy Bean Isoflavon on Lipid Accumulation in 3T3-L1 Adipocytes
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چکیده
منابع مشابه
Development of a Novel Anti-Obesity Compound with Inhibiting Properties on the Lipid Accumulation in 3T3-L1 Adipocytes
Background: Obesity as a developing global challenge can be characterized by increase in adipocyte number and size arising from adipogenesis. Control of adipogenesis, as a potential strategy, can prevent and manage obesity. So far, the effectiveness of herbal medicine and active ingredients therapies for obesity and metabolic syndrome treatment has been investigated. In this study, a novel comb...
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Background Obesity is considered the major risk factor for type 2 diabetes mellitus (T2DM), cardio-vascular diseases like hypertension and atherosclerosis [1]. Catechins are the major source of flavonols and they are comprised of various types of catechins such as epigallo catechin 3 gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG) [2]. Numbers of in vivo studies have reported ...
متن کاملCarnosic Acid Inhibits Lipid Accumulation in 3T3-L1 Adipocytes Through Attenuation of Fatty Acid Desaturation
BACKGROUND Excess body fat accumulation contributes to the development of metabolic disorders that can cause adverse health effects. Carnosic acid (CA), a major bioactive component of rosemary (Rosemarinus officinalis), has been suggested to possess anti-adipogenic properties. The present study was conducted to elucidate the mechanism underlying the anti-adipogenic effects of CA. METHODS 3T3-...
متن کاملEffects of lipoic acid on lipolysis in 3T3-L1 adipocytes.
Lipoic acid (LA) is a naturally occurring compound with beneficial effects on obesity. The aim of this study was to evaluate its effects on lipolysis in 3T3-L1 adipocytes and the mechanisms involved. Our results revealed that LA induced a dose- and time-dependent lipolytic action, which was reversed by pretreatment with the c-Jun N-terminal kinase inhibitor SP600125, the PKA inhibitor H89, and ...
متن کاملCycloastragenol, a triterpene aglycone derived from Radix astragali, suppresses the accumulation of cytoplasmic lipid droplet in 3T3-L1 adipocytes.
Cycloastragenol (CAG), a bioactive triterpenoid sapogenin isolated from the Chinese herbal medicine Radix astragali, was reported to promote the phosphorylation of extracellular signal-regulated protein kinase (ERK). Here we investigated the effect of CAG on adipogenesis. The image-based Nile red staining analyses revealed that CAG dose dependently reduced cytoplasmic lipid droplet in 3T3-L1 ad...
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ژورنال
عنوان ژورنال: Journal of Biosciences and Medicines
سال: 2015
ISSN: 2327-5081,2327-509X
DOI: 10.4236/jbm.2015.39008